
| 2000 Mellon Bank | |||
| Opponent | Date | Score | Slogan | 
| 
 | 
 | 
 | 
 | 
| USC (Giants Stadium) | 8-27-00 | L 5-29 | Southern Cal Can’t | 
| Toledo | 9-2-00 | L 6-24 | No Free Launch Here | 
| Louisiana Tech | 9-9-00 | W 67-7 | All Bark and No Bite | 
| at Pittsburgh | 9-16-00 | L 0-12 | Lions Gitt itt Done | 
| at Ohio State | 9-23-00 | L 6-45 | Outta Luck-Eyes | 
| Purdue | 9-30-00 | W 22-20 | Take the Steam Out | 
| at Minnesota | 10-7-00 | L 16-25 | |
| Illinois | 10-21-00 | W 39-25 | ill-advised | 
| at Indiana (RCA Dome) | 10-28-00 | W 27-24 | Indi-gestion | 
| Iowa | 11-4-00 | L 23-26 | Fowled Out | 
| at Michigan | 11-11-00 | L 11-33 | Ann Arbor, Who’s She? | 
| Michigan State | 11-18-00 | W 42-23 | MSU - Green With Envy |